QC Analyst I

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking QC Analyst I as part of the Quality team based in Raritan, NJ. 

Role Overview

The QC Analyst is an exempt level position with responsibilities for performing QC testing related to the manufacturing of cell therapy products for clinical trials and commercial operations in a controlled GMP environment.

Key Responsibilities  

• Be responsible for the completion of QC testing related to the manufacturing of autologous CAR-T products for clinical trials and commercial operation in a controlled cGMP cleanroom environment.
  
• Ensure testing is completed in compliance with all applicable procedures, standards and GMP regulations.
  
• Conduct analytical testing of raw material/utility, in-process, or final product samples submitted to the QC laboratories.
  
• Perform peer review/approval of laboratory data.
  
• Utilize electronic systems (LIMS) for execution and documentation of testing.
  
• Create, review and approve relevant QC documents, SOP’s and WI’s.
  
• Perform tasks in a manner consistent with the safety policies, quality systems and cGMP requirements.
• Work in a collaborative team setting with quality counterparts that include Quality Assurance, Manufacturing Operations, and Analytical/Process Development.
  
• Job duties performed require routine exposure to and handling of biological materials and hazardous chemicals.

Requirements

• Bachelor’s Degree in Science, Engineering or equivalent technical discipline is required.
  
• Minimum of 1 year relevant work experience, preferably within a biological and/or pharmaceutical industry is required.
  
• Experience in a Quality Control setting is preferred.
  
• Experience with processing samples in biosafety cabinets utilizing aseptic technique is strongly preferred.
  
• Knowledge of cGMP regulations and FDA/EU guidance related to manufacturing of cell-based products is strongly preferred.
  
• Knowledge of Good Tissue Practices is required.
  
• Knowledge of CAR-T QC test methods and related equipment is preferred.
  
• Excellent written and oral communication skill are required.
• Candidates must be able to accommodate shift schedule. Shifts include routine weekend and evening work as required by the manufacturing process.
  
• Candidates must be able to accommodate unplanned overtime (including nights and weekends) on little to no prior notice.
  
• The candidate must be highly organized and capable of working in a team environment with a positive attitude under some supervision.
  
• Comfortable with speaking and interacting with regulatory inspectors.
  
• This position may require occasional travel to partner sites in NJ or PA as business demands.
  
• This position may require up to 5% domestic or international travel as business demands.
  
• Ownership and Commitment
  • Takes responsibility for one's results and deliverables; sets and achieves goals to support organizational priorities.
    
  • Takes initiative; willing to take unpopular positions/actions when necessary; courageous and assertive.
    
  • Works effectively in the face of ambiguity, shifting priorities, and rapid change; maintains a positive outlook in difficult situations; a change agent.
• Agility and Prioritization
  
  • Identifies and focuses on activities of highest value and impact; makes informed decisions quickly.
    
  • Results oriented; defines goals, metrics and actionable plans and manages work to deliver desired outcomes; has a sense of urgency.
  • Considers resources, alternatives, constraints and desired outcomes to make effective decisions.
  • Employs good project management principles to appropriately align time, resources, and budgets.
• Teamwork and Communication
  • Appreciates diverse perspectives and is actively inclusive of others' input and ideas; treats others with respect.
  • Articulates ideas clearly and succinctly in a variety of settings and styles; can get messages across that have the desired effect.
  • Leverages personal credibility and interpersonal skills to help others make better decisions and positively impact outcomes; able to develop/maintain effective working relationships internally and externally
  • Employs a global mindset in decision-making and errs on the side of over-communicating to create organizational transparency, trust and alignment.
• Continuous Improvement
  • Takes initiative, actively shares knowledge, builds skills, promotes new ideas and embraces change.
  • Generates new solutions to problems by challenging the status quo and conventional thinking.

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.