Scientist - II
Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs
Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs.
Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology
Initiate or help manage projects with external vendors or collaborators
Execute research activities under limited supervision
Provide critical analysis and interpretation of data
Deliver reporting and communication of results, and participate in scientific discussions
Experience & Expertise
A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required.
Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred.
Experience with tissue culture and functional cellular immunology assays desired
Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired.
Ability to work independently with minimal supervision in a team environment.
Proficiency in working with complex data sets and interpreting and presenting results.
Knowledge of data analysis and visualization applications.
Effective oral, written and interpersonal communication skills.
Technical Knowledge and Skills:
Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production.
Experience in protein detection assays including ELISA, MSD, Singulex, etc.
Experience with FACS immunophenotyping and sorting of human cells.
Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research.
Qualifications
Education Qualification:
Only MS or PhD candidates are needed.