Associate Director, Medical Affairs
$184k - $227k USD
Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).
Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.
The Opportunity
The Associate Director, Medical Affairs is a strategic, execution‑focused role responsible for translating Medical Affairs strategy into high‑impact operational delivery across multiple therapeutic areas. While the initial priority will be post‑bariatric hypoglycemia, this person will also support efforts in Wolfram syndrome and ALS.
They will drive the operationalization of scientific plans, advance launch readiness, and strengthen Medical Affairs excellence in a dynamic, fast‑paced, pre‑launch environment. This is a hands‑on role suited for someone who excels at scientific execution, manages external partners effectively, and leads cross‑functional initiatives through collaboration and influence. A core responsibility of this role is to develop and scale foundational Medical Affairs capabilities—including publication planning, congress strategy and execution, professional society engagement, MLR leadership, insights governance, and field medical enablement. This person will also play a critical role in shaping cross‑functional strategy by ensuring scientific rigor, translating insights into action, and fostering strong alignment across functions.
This position is ideal for a scientifically rigorous, highly motivated Medical Affairs leader who thrives in a dynamic environment, enjoys taking ownership of high‑visibility work, and is eager to contribute meaningfully to a growing portfolio. As the organization evolves, the role offers clear opportunities to expand scope and advance into broader leadership responsibilities while driving impact for communities with significant unmet needs.
Responsibilities
- Execute end-to-end scientific communications plans across therapeutic areas, including publications, abstracts, congress content, and medical information alignment
- Lead execution of congress strategy and Medical Affairs presence, ensuring seamless planning, coordination, and delivery of impactful scientific engagement
- Serve as primary medical reviewer (MLR) for assigned materials; escalate critical items as needed
- Own the medical insights system and lead monthly insights meetings to inform cross-functional strategy
- Deliver scientific training modules for the field team and support onboarding of new field team members
- Ensure field teams receive high-quality, consistent, evidence-based scientific content.
- Partner with HEOR, Advocacy, Field Medical, R&D, and Commercial teams to ensure alignment and support launch readiness
- Contribute to the development and continuous improvement of Medical Affairs processes, SOPs, and operating frameworks
Required Qualifications
- Advanced scientific degree (MD, PhD, PharmD or equivalent)
- 3-5 years of experience in Medical Affairs or related field, with multi-TA exposure preferred
- Strong organizational and project management skills, with an ability to lead multiple high-priority initiatives in a dynamic, pre-launch environment.
- Excellent communication, scientific writing, and stakeholder-management skills.
Preferred Qualifications
- Experience leading or contributing to medical insights processes and synthesizing complex information
- Proven track record in scientific communications, congress activities, and MLR review
- Experience in rare disease or metabolic/endocrine conditions
Work Location and Conditions
- At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
- You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation.
- You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location
Compensation
The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.
Estimated Pay Range
$184,000—$227,000 USD
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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
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