Computational Biology - Postdoctoral Researcher

Note: This is a two-year Postdoctoral appointment with the possibility of extension to a maximum of three years.

We have an opening for a Postdoctoral Researcher to conduct research in the areas of computational systems biology. This research will involve development and use of detailed system-level models of metabolism in microbial communities and development of novel constraint-based modeling methods.  These models and tools will be used to examine the biochemical mechanisms of intercellular interactions. This research could involve development of multiple types of models including genome-scale steady state models, reaction-transport dynamic models, and some ML models.  Some of the modeling efforts involve use of LLNL’s high-performance computing. The position is part of a larger project aiming to develop comprehensive understanding of the systems level resource allocation consequences of microscale symbioses between microbes and bioenergy and bioproduct relevant crops (https://bio-sfa.llnl.gov). The purpose of this appointment is to promote cutting-edge science and requires day-to-day interactions with experimental biologists.  This position is in the Biochemical and Biophysical Systems group of the Biosciences and Biotechnology Division. 

This position requires full-time on-site presence due to the nature of the work.

You will 

• Conduct research in computational microbiology in the areas of microbial ecology and microbial community engineering.
• Develop genome-scale models of metabolism in bacteria and algae.
• Develop spatially multiscale dynamic reaction and transport models of biophysical systems.
• Investigate the system-level underpinnings of processes involved in symbiotic interactions between algae and bacteria in co-cultured communities. 
• Examining interaction between microbes and the surrounding medium using methods such as dynamic flux balance analysis and flux sampling.
• Contribute to the conception, design and execution of experiments and in silico analyses to address defined problems.
• Communicate with experimental biologists for systems biology studies.
• Develop new computational tools for high performance computing studies.
• Work in a collaborative multidisciplinary team environment to accomplish goals.
• Publish research in peer-reviewed journals and present research at conferences.
• Perform other duties as assigned.

Qualifications

• PhD in microbiology, bioengineering, computer science, chemistry/biochemistry, physics or related field.
• Demonstrated understanding of the concepts of microbial physiology (particularly metabolism), systems biology and dynamics of multi-cellular communities.
• Previous experience in mathematical modeling of networks.
• Experience in bioinformatics and computational analyses.
• Familiarity with system-level modeling methods like FBA and tools like COBRA.
• Demonstrated effective communication skills through publication of journal articles and presentations at seminars and scientific meetings.
• Demonstrated leadership skills with desire and ability to work in a collaborative, multidisciplinary team environment.  

Qualifications We Desire

• Familiarity with programming for parallel computing.
• Experience using tools of linear programming and operations research.

Additional Information

#LI-Onsite

Position Information

This is a Postdoctoral appointment with the possibility of extension to a maximum of three years, open to those who have been awarded a PhD at time of hire date.

Why Lawrence Livermore National Laboratory?

• Included in 2026 Best Places to Work by Glassdoor!
• Flexible Benefits Package
• 401(k)
• Relocation Assistance
• Education Reimbursement Program
• Flexible schedules (*depending on project needs)
• Our values - visit https://www.llnl.gov/inclusion/our-values

Security Clearance

None required.  However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process.  This process includes completing an online background investigation form and receiving approval of the background check.  

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External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

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