Director, Clinical Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Associate Director, Clinical Development will contribute to the scientific, clinical, and operational scope of assigned study protocols. This role will work with the cross-functional teams for the design, execution, and monitoring of clinical studies, as well as oversee data review, interpretation, and communication to both internal and external stakeholders. Oncology and/or late-stage experience is preferred. 

• Develop and execute clinical development strategies and the Clinical Development Plan (CDP) with a focus on early-phase development.

• Lead cross-functional teams with oversight from senior team members to conduct clinical studies, including study start up, execution and close out activities, data review/analysis, and preparation of study reports.

• Oversee the development of program-level documents, including but not limited to clinical protocols, investigator’s brochure, clinical study reports, abstracts and manuscripts, presentations, and various other internal and external documents and communications as needed.

• Conduct ongoing data reviews; prepare and present summaries to internal and external stakeholders.

• Ensure trial implementation according to the protocol and analyze information to assess issues relating to protocol conduct and/or individual subject safety.

• Interact with internal and external stakeholders (investigators, study sites, vendors, committees, etc.) in support of clinical trial objectives; responds to or triages questions for appropriate escalation.

• Conduct literature reviews as needed.

• Travel: Up to 20%.

Required Skills, Experience and Education:

• A PhD, PharmD or equivalent is required. The years of experience are based on clinical development or similar relevant experience.

• Minimum 8+ years of experience in the pharmaceutical or biotechnology industry as a clinical scientist or related role.

• Proven leadership in a collaborative team setting and driven by a desire to deploy innovative approaches and technologies in a high-energy environment.

• Detail-oriented with ability prioritize tasks and function independently as appropriate.

• Strong organizational skills and an ability to interpret, discuss, and report trial/program level data effectively and identify trends.

• Proficient with software tools (Microsoft Office), Electronic Data Capture, and other custom web-based software.

• Excellent written and verbal communication skills.

Preferred Skills:

• Strong experience with clinical data review and data quality assurance.

• Knowledge and experience with clinical trial management and oversight.

• Understanding and experience in clinical trial protocol and regulatory document authoring. 

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