Manager, Commercial Operations

Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions.

The Manager of Commercial Operations will help scale Karius’ commercial organization by building and optimizing processes, systems, and data infrastructure that improve performance and enable cross-functional execution. This role serves as a strategic and operational partner to Sales Leadership, Customer Success, Marketing, Finance, and Lab/Operations teams by translating business needs into actionable insights, scalable workflows, and governed execution across the commercial lifecycle. This role will own the operating rhythm for key commercial processes (pipeline hygiene, forecasting, deal support, reporting, and data governance), ensuring high-quality outputs that are stakeholder-ready and drive measurable impact.

Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.

Reports to: Senior Director, Commercial Operations and Customer Success

Location:  Redwood City, CA (Hybrid) or Remote (USA)

•  Lead improvements to commercial processes and workflows across the go-to-market lifecycle (lead-to-opportunity-to-order-to-cash), ensuring clarity, consistency, and adoption.

•  Partner with stakeholders to identify process gaps, define requirements, and deliver scalable solutions across CRM (Salesforce), marketing systems (HubSpot), and downstream integrations.

•  Maintain governance of commercial master data (accounts, contacts, territories, referring institutions, attribution rules, etc.), including documentation and quality controls.

•  Build and maintain process documentation, SOPs, and training materials to ensure consistency and enablement.

•  Own the Commercial Ops intake and ticketing process (e.g., JIRA/other), including required fields, prioritization, assignment, and closure standards.

•  Maintain clear SLAs (e.g., 48-hour response/turnaround where applicable), proactively communicating risks, dependencies, and timeline changes before deadlines slip.

•  Maintain a transparent tracker/backlog for all workstreams and requests, including priority, owner, due date, dependencies, and next steps.

•  Partner with the Commercial Operations leader to drive pipeline discipline, forecasting accuracy, and consistent inspection routines (weekly/monthly/quarterly).

•  Support annual comp, quota/goal, and territory planning (analysis, scenarios, and execution) in partnership with the Commercial Operations leader.

•  Own pipeline and funnel reporting, including stage definitions, conversion metrics, velocity, and leading indicators.

•  Ensure consistent reporting definitions and governance, and maintain stakeholder trust in metrics and reporting.

•  Develop and maintain dashboards and reporting that provide clear visibility into performance, pipeline, activity, and operational health.

•  Design and develop complex queries, comprehensive reports, and analyses to facilitate fact-based business decisions.

•  Perform business intelligence and analytics reporting to support commercial and field team initiatives.

•  Translate analysis into decision support: succinct insights, implications (“so what”), recommendations, and execution next steps with owners and timelines.

Create stakeholder-ready outputs (leadership updates, summaries, dashboards, and analyses) with minimal rework required. 

•  Establish reporting definitions, QA checks, and governance to ensure accuracy and stakeholder trust

•  Support deal execution and deal desk processes as needed (quoting, approvals, routing, contracting coordination), ensuring accuracy and speed.

•  Partner with Finance/Ops/Legal as appropriate to ensure contract and deal workflows are executed correctly and on time.

•  Partner with Marketing and Sales to define and govern lead flow, handoffs, SLAs, attribution, and event ROI reporting by translating performance into clear recommendations for future investment.

•  Drive enablement for commercial process changes by tailoring training and communications for a field audience to ensure adoption.

You will have the opportunity to build and optimize critical commercial systems that drive the growth and success of Karius. You’ll work closely with various teams across the organization, gaining a comprehensive understanding of the business while contributing to impactful projects that support the company’s mission to transform healthcare.

Travel:  Travel required up to 25%   

Physical Requirements:  Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, lab or clinical environment.

•  Bachelor’s degree required; graduate degree preferred. 

•  A minimum of 6-8 years of experience; Master’s degree with 4-6+ years of experience in Commercial Operations, Sales Operations, Revenue Operations, Business Operations, or related function in a high-growth environment. 

•  Extensive CRM and commercial systems experience (Salesforce and BI tools required; HubSpot, JIRA/Asana preferred).

•  Proven ability to build scalable processes, governance, and operating rhythms across cross-functional stakeholders.

•  Strong analytical skills with the ability to translate data into actionable business recommendations.

•  Excellent project management and execution skills, including prioritization, tracking, dependency management, and on-time delivery.

•  Proven ability to communicate with clarity and concision across levels, including senior leadership and field teams.

•  High attention to detail with experience implementing QA controls and maintaining data integrity.

•  Experience supporting healthcare, diagnostics, lab operations, or regulated environments.

•  Mission-driven and aligned with improving patient outcomes through operational excellence.

•  Operates with high accountability: sets clear plans, manages dependencies, flags risks early, and consistently delivers on commitments.

•  Detail-oriented with strong judgment; applies quality checks to ensure accuracy and reduce rework.

•  Strong communicator who provides direct answers, crisp summaries, and clear next steps for stakeholders and leadership.

•  Naturally collaborative—builds alignment across Sales, CS, Marketing, Finance, and Operations, and can drive adoption of change.

•  Curious and analytical; connects data to the “so what” and recommends actions.

•  Performs well in fast-paced environments with evolving priorities and imperfect information.

•  Ability to work effectively and efficiently in a fast-paced (startup) environment.

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius.

At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at recruiting@kariusdx.com and we will accommodate qualified individuals with disabilities.