Scientist, Bioinformatics

About Arc Institute

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

• Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.
• Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
• Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
• Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.

About the position

The Arc Institute is seeking a Bioinformatics Scientist to join the Bioinformatics team within the Computational Technology Center. The successful candidate will play a crucial role in advancing Arc Institute's Initiatives, including the Virtual Cell Initiative (VCI)—developing machine learning models to predict cellular behavior and identify therapeutic targets for complex diseases—and the Alzheimer's Disease Initiative (ADI), which aims to understand the fundamental causes of Alzheimer's disease.

About you

• You are passionate about science and excited about answering biological questions related to complex human diseases.
• You are known for your ability to analyze complex datasets and work effectively in a multidisciplinary team. 
• Your organizational skills enable you to manage multiple concurrent projects, and your curiosity and creativity drive you to continuous learning and innovation.
• You possess outstanding scientific coding and software engineering skills.

In this position you will

• Implement, test, and maintain state-of-the-art analysis pipelines for various high-throughput projects using best software engineering practices.
• Analyze large-scale sequencing datasets (single-cell RNA-seq, epigenomics, multi-omics, Perturb-seq, spatial transcriptomics), public and generated in-house.
• Communicate analysis results to experimental and computational scientists.
• Assist others in utilizing software packages and pipelines.

Requirements

• Ph.D. in Bioinformatics, Computational Biology, Computer Science, or related quantitative field.
• Hands-on experience analyzing high-throughput sequencing datasets, especially on single-cell omics data.
• High competency with Python, git/GitHub, and Linux.
• Ability to collaborate with wet-lab scientists.
• Strong statistical, mathematical, analytical, and data science skills.

Preferred Qualifications

• Strong software engineering skills.
• Familiarity with CRISPR screens technology and analyses.
• Scientific background in functional genomics.
• Familiarity with cloud computing.

The base salary range for this position is $112,500 to $186,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.