Scientist/Senior Scientist, Preclinical Development and Translational Science
$120k - $180k USD
COMPANY
Volastra Therapeutics, Inc. is a clinical-stage oncology biotech company based in New York City, pioneering novel approaches to treating cancer by targeting chromosomal instability (CIN), a unique vulnerability in cancer. Since its founding in 2019, Volastra has grown to support ongoing discovery efforts and a growing clinical organization.
Our lead pipeline programs focus on two distinct inhibitors of KIF18A, a novel therapeutic target. VLS-1488, internally discovered, entered clinical trials in Q4 2023 for the treatment of advanced cancers. Sovilnesib, in-licensed from Amgen in 2023, re-entered the clinic in Q2 2024. Both assets have been granted Fast-Track Designation by the FDA. Volastra is also developing new techniques to understand the biology of chromosomal instability and leveraging these insights to drive forward a preclinical pipeline of therapies against innovative targets.
Volastra is backed by top US and European venture firms such as Arch, Polaris, Vida, Droia, Catalio, and B Capital, alongside strategic investment from Eli Lilly. In addition to venture funding, Volastra has established partnerships with oncology leaders. Our senior leadership team is highly experienced, supported by a world-class advisory board.
We are headquartered in West Harlem, New York City, within easy reach of Columbia, Cornell, Memorial Sloan Kettering, and surrounding areas. Please visit www.volastratx.com for more information.
JOB DESCRIPTION:
The role of Scientist/Senior Scientist of Preclinical Development and Translational Science will report to the Senior Director of Translational Science and Biomarkers, and work towards the successful execution of both preclinical development programs and pertinent translational science investigations. The ideal candidate will have both strong laboratory skills and preclinical biomarker experience, is detail-oriented and self-motivated, with highly relevant experience.
Volastra is a fast-paced biotech company of passionate employees, and there is ample opportunity for the ideal candidate to grow and develop with the organization. Individuals will have, from time to time, the opportunity to gain experience with projects outside their direct scope of work.
Job is based in NYC and requires a minimum of 80% in office time.
RESPONSIBILITIES:
• In collaboration with other members of the Translational Science and the Discovery Science team, design and execute experimental plans to answer important translational questions to inform clinical development plans
• Coordinate and oversee studies at contract research organizations
• Execution and development of existing and/or new assays and assay strategies related to biomarker application and validation
• Coordinate activities and timelines with Development teams to ensure seamless execution of biomarker capabilities to support clinical trials
• Work closely with relevant team members to analyze, interpret and communicate translational results
• Assist in preparation of relevant documents and reports including meeting presentations, biomarker reports, and regulatory submission documents.
REQUIREMENTS:
• MS in related field, PhD a plus but not required
• 2+ years of industry experience in preclinical development and clinical oncology biomarker
• 5+ years of hands-on lab experience with a range of relevant research techniques including cell-based assays, molecular biology, and histology. In vivo mouse experience is preferred
• Knowledge of antibody drug conjugates (ADC) biology and broad experience with in vitro and in vivo ADC testing
• Experience in the development and validation of biomarker assays suitable for clinical samples
• Track record of successfully managing external projects with CRO’s from scoping to final data delivery
• Understanding of the drug development process from target identification to marketing authorization
• Basic understanding of regulatory aspects of medical diagnostics
• Excellent communication, organizational, and problem-solving skills
Salary Range:
Approximately $120,000 - $180,000 which may vary depending on qualifications, experience, and ultimate leveling. Leveling outside of that stated may be considered for exceptional candidates on a case-by-case basis.