Senior Director, Health Economics and Outcomes Research (HEOR) Analytics

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X.

About This Role  

Axsome Therapeutics is seeking a Senior Director, Health Economics and Outcomes Research (HEOR) Analytics to lead the design and execution of real-world evidence (RWE) analytics in support of the value proposition of Axsome’s marketed products and pipeline assets. Reporting to the Associate Vice President of Health Economics & Evidence Generation Strategy, the Senior Director, HEOR Analytics will provide hands-on technical expertise and day-to-day partnership with cross-functional teams. The Senior Director HEOR Analytics will oversee complex real-world data (RWD) analyses, ensure methodological rigor, and mentor a team with expertise in real world analysis design, execution, and interpretation.  

This role requires deep expertise in analyzing large-scale healthcare datasets—including administrative claims and electronic health records (EHR)—to generate insights that inform medical affairs, market access, and commercial strategies as needed. HEOR Analytics Lead will work in close partnership with HEOR Product Leads to develop fit-for-purpose analytical plans, with additional input from Medical Directors, Health Outcomes Liaison (HOL) team members, and other cross-functional partners as necessary.  

This role is based at Axsome’s HQ in New York City with an on-site requirement of at least three days per week. We are unable to consider candidates who are looking for fully remote roles.  

Job Responsibilities and Duties include, but are not limited to, the following: 

Technical Leadership & Methodology 

• In partnership with HEOR Leads, design and execute observational research using real-world data sources (claims, EHR, registries) to assess disease burden, treatment patterns, real-world outcomes, and unmet needs 

• Develop advanced analytical approaches including predictive models, comparative effectiveness studies, causal inference frameworks, and longitudinal analyses 
• Ensure methodological rigor in study design(e.g., propensity score matching, IPTW) and advanced statistical modeling 

Data Management & Analytics Execution 

• Lead the integration, management, and analysis of large healthcare databases, including Komodo, Symphony, MarketScan, and EHR databases 

• Implement data cleaning, transformation, and quality assurance processes for high-volume datasets 

• Utilize programming languages (SAS, R and Python to develop statistical models, generate outputs, and visualize results 
• Partner with HEOR Leads and other internal stakeholders to shape Axsome’s real-world data strategy, including evaluating new datasets and potential partnerships  

Evidence Generation & Dissemination 

• Develop statistical analysis plans and oversee high-quality programming deliverables (analysis-ready datasets, tables, and figures) while establishing best practices across teams 

• Contribute to observational study protocols and analysis documents 

• Author and co-author peer-reviewed publications, conference abstracts, and presentations 

• Translate analytical findings into insights that support payer negotiations, value dossiers, medical strategies, and commercial planning 
• Deliver clear, compelling presentations of technical results to non-technical stakeholders 

Leadership & Team Development 

• Manage and mentor a team of real-world evidence analysts, biostatisticians and data scientists, fostering technical excellence and innovation. 

• Oversee resource planning, performance management, and career development for direct reports 

• Drive best practices, innovation, and continuous improvements in HEOR analytics processes and methodologies,  
• Stay current on evolving RWE methodologies, regulatory guidance, and payer expectations; proactively educate internal partners 

Requirements / Qualifications 

• PhD or Master’s in Biostatistics, Epidemiology, Health Economics, or related quantitative discipline 

• 10+ years in HEOR/RWE analytics within the pharmaceutical or biotech industry 

• Minimum of 5 years of people management, team leadership and mentoring experience 
• Ability to work on site Monday, Tuesday & Thursday. We are unable to consider candidates who are looking for fully remote roles 

Experience, Knowledge and Skills 

• Proven experience analyzing large-scale claims and EHR datasets 

• Advanced proficiency in SAS, R, and/or Python for statistical programming 

• Deep expertise in study design and advanced statistical methods (e.g., survival analysis, mixed models, machine learning) 

• Strong publication record in peer-reviewed journals 

• Demonstrated success in using innovative analytical techniques to overcome real‑world data limitations.  

• Knowledge of health economic modeling, patient-reported outcomes (PROs), and outcomes research methods preferred 

• Ability to impact, influence, and interact with senior business leaders and partners 

• Experience with payer evidence requirements, dissemination strategies, and reimbursement/access environments  

• Excellent communication and interpersonal skills across departments and geographic locations 

• Experience managing budget and resource allocation 

• Ability to lead, collaborate, and influence in a matrix, fast-paced environment 

• Flexible, adaptable, diplomatic, and comfortable navigating ambiguity 

• Strong attention to detail with the ability to balance strategic and operational responsibilities 

• Ability to manage multiple priorities aligned with program objectives  
• Launch experience strongly preferred 

Salary & Benefits  

The anticipated salary range for this role is $260,000 – $285,000. We encourage candidates of all levels to apply as there may be flexibility on final job title and responsibilities. The salary offer will be based on a variety of factors, including experience, qualifications, internal equity and location. Axsome offers a competitive employment package that includes an annual bonus, significant equity and a generous benefits package. 

Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities. We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law. 

Axsome Therapeutics does not accept unsolicited resumes from recruiters or third-party recruitment agencies and will not pay placement fees for unsolicited candidates that are sent to hiring managers, the HR team or other Axsome team members. Only approved vendors who have been explicitly asked to support a specific search will receive access to our Applicant Tracking System to submit candidates for consideration.