Senior Scientist I, Clinical Biomarker Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

• Define and execute translational and biomarker strategies for Revolution Medicine’s clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.

• Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program. 

• Manage external biomarker analysis at contract research organizations (CROs) including experimental design, fit-for-purpose validation, budgeting, timelines, oversight of clinical implementation, and data analysis during trial conduct. 

• Collaborate with Translational Medicine team members in biomarker operations and clinical bioinformatics on executing biomarker plans.

• Evaluate new technologies to enable exploratory biomarkers. 

• Represent Translational Medicine within project/program teams; analyze, interpret, and present biomarker results, meet project/program milestones for TM responsibilities.

• Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications. 

• Effectively collaborate across internal functions including translational sciences, clinical development, clinical operations, biostatistics, data management, and clinical pharmacology to ensure successful execution in the clinic.

Required Skills, Experience and Education:

• Ph.D. or equivalent in Cancer Biology, Immunology, Cell/Molecular Biology or related. 

• Employer will accept a Master’s degree or equivalent in Cancer Biology, Immunology, Cell/Molecular Biology or related and three (3) years of experience in biological data analysis in lieu of a Ph.D. or equivalent as described above.

• Academic coursework, internship or work experience to include:

• Analyzing biological data using Excel, GraphPad Prism, or equivalent tools;

• Hands-on experience with development and validation protocols of in vitro, in vivo, or clinical biomarker oncology assays;

• Managing and communicating with contract research organizations for biomarker testing and analysis (assay design, validation, testing conduct, timelines, data delivery);

• Experience preparing and presenting scientific presentations for internal meetings;

• Experience developing or analyzing data from methodologies such as next generation sequencing, ribonucleic acid sequencing (RNAseq), quantitative polymerase chain reaction (qPCR), immunohistochemistry, or multiplex immunofluorescence.