Director, Health Economics & Outcomes Research (HEOR)

The Role:

Reporting to the Senior Director, HEOR, the Director of Health Economics & Outcomes Research will lead U.S. and Global HEOR strategy for Nuvalent’s portfolio, shaping value evidence to enable optimal patient access and inform coverage, reimbursement, and utilization decisions. You will design and deliver HEOR/RWE studies, develop payer-facing economic/decision tools, support pre-, peri-, and post-launch planning, and foster cross-functional collaboration across Medical Affairs, Market Access, Regulatory, Commercial, Clinical Development, and Biostatistics. You’ll also play a visible role educating the organization on the evolving U.S. and Global HTA environment.

This is an ideal opportunity for a scientifically strong, execution-oriented leader who enjoys pairing strategic planning with hands-on delivery in a fast-paced setting.

Responsibilities:

Strategy, Governance & Planning

• Lead the U.S. & Global HEOR strategy and integrated evidence planning for Nuvalent assets, aligned with Medical Affairs, Market Access, Regulatory, and Commercial priorities.
• Standardize and optimize data generation policies, processes, and SOPs to ensure quality, compliance, and scalability.
• Develop the annual HEOR tactical plan and budget; manage timelines, vendors, and scope to achieve defined objectives.
• Serve as the internal HEOR point of contact for evidence generation needs, services, and technologies; proactively represent payer/IDN evidence needs in cross-functional planning.
• Educate and upskill teams on HEOR, evidence-based medicine, U.S. reimbursement trends, and Global HTA dynamics.

Evidence Generation & Publications

• Design, lead, and complete HEOR/RWE studies (e.g., observational studies, claims/EMR/registry analyses, PRO development/validation, burden of illness, unmet need).
• Own research plans, protocols, budgets, and timelines; oversee analyses and author abstracts, posters, manuscripts, and internal reports.
• Partner with Clinical Development and Biostatistics/Evidence Generation to optimize study design, endpoints, data sources, and analyses.
• Collaborate with Medical Information/Scientific Communications to inform U.S./Global publication plans and ensure consistent, compliant value messaging.

Economic & Decision-Support Tools

• Lead development of AMCP/Global dossiers, Budget Impact Models (BIMs), Cost-Effectiveness Analyses (CEA), ITCs/NMAs, Systematic Literature Reviews (SLRs), and payer pull-through materials.
• Support ICER assessments and responses (as applicable) and monitor HTA implications (e.g., NICE, CADTH, etc.) for brand strategy.

External Engagement & Field Support

• Identify and collaborate with KOLs/COEs on study design, authorship, and advisory boards; conduct payer advisory boards to track evolving evidence requirements.
• Engage payers, IDNs, PBMs, specialty pharmacies, and other decision makers via compliant scientific exchange to inform evidence needs and communicate value.
• Provide field-based scientific/HEOR support and tools to Market Access and medical field teams.

Cross-Functional Partnership & Launch Excellence

• Partner with Brand/Commercial and Market Access to shape value narratives and pull-through while maintaining scientific integrity and compliance.
• Contribute to or lead high-priority medical initiatives, integrated evidence planning workshops, advisory boards, and cross-functional launch planning across U.S. and Global teams.
• Maintain in-depth knowledge of the evolving healthcare environment and HTA to anticipate evidence needs and inform strategy.

Competencies:

• Strategic & hands-on: Equally comfortable setting strategy and rolling up sleeves to deliver.
• Collaboration & influence: Builds trust and productive relationships with internal leaders and external stakeholders.
• Innovation & problem solving: Encourages new ideas; integrates evidence from multiple sources to drive decisions.
• Operational excellence: Creates scalable capabilities, processes, and procedures; manages ambiguity and complexity.
• Results orientation: Performance-driven; proactively addresses risks, conflicts, and tradeoffs to deliver on time and on budget.
• Executive communication: Translates complex science and economics into clear, business-relevant insights.

Qualifications: 

• Doctoral degree (PhD, PharmD, MD/DO).
• 7–10+ years of relevant pharma/biotech HEOR/RWE experience.
• Oncology experience (3+ years), preferably NSCLC; U.S. and Global launch experience.
• Demonstrated expertise with U.S. and Global RWD (claims, EMR, registries) and payer landscapes.
• Hands-on experience with HEOR modeling (BIM/CEA), observational methods, and PROs; familiarity with statistics.
• Proven ability to work independently and collaboratively in fast-paced, cross-functional environments and manage multiple complex projects.
• Outstanding communication and presentation skills, including executive-level briefings and external thought leader engagement.
• U.S.-based remote role with periodic travel for internal meetings, congresses, advisory boards, and select payer/KOL engagements (~10–20% domestic; occasional international as needed).

Preferred

• Experience supporting ICER and engaging with Global HTA bodies (e.g., NICE, CADTH).
• Track record building departmental capabilities, SOPs, and scalable vendor/operational frameworks.
• Established relationships across payers/IDNs/PBMs and oncology KOLs/COEs.
• Knowledge of medical communications trends and best practices.

Additional Information:

Nuvalent is committed to fair and equitable compensation practices, aiming to provide employees with competitive total rewards packages.

The targeted salary range below reflects what Nuvalent reasonably and in good faith expects to offer for this position at the time of posting, but the final salary determination may be within or outside this range based on various factors, including, but not limited to, experience, skills, education, and market factors.  The range will be reviewed regularly and is subject to change.

Nuvalent also offers a comprehensive benefit package to support our employees at each stage of their career, financial, health, and well-being journey, including medical, dental, and vision insurance, 401(k) retirement savings plan, generous paid time off (including a summer and winter company shutdown), and much more.

Nuvalent provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.