Principal Scientist, Translational Neuroscience
About Us
Bexorg is a cutting-edge biotech startup focused on CNS drug discovery, leveraging its proprietary BrainEx platform to conduct preclinical studies on molecularly active, postmortem human brains. We combine advanced wet-lab experiments with AI/ML-driven drug discovery to revolutionize the understanding and treatment of brain disorders. We are seeking a Principal Scientist with deep expertise in translational biomarkers for neurological diseases, to contribute to our groundbreaking R&D efforts.
The Role
We are looking for a highly motivated and experienced Principal Scientist to lead efforts to identify and characterize translational biomarkers for our drug discovery programs. The ideal candidate will have extensive knowledge of preclinical and clinical biomarkers for Alzheimer’s, Parkinson’s or other neurodegenerative diseases. This is a full-time, on-site position requiring physical presence in our state-of-the-art facilities to conduct hands-on research and collaborate directly with cross-functional teams.We are looking for a highly motivated and experienced Principal Scientist to lead efforts to identify and characterize translational biomarkers for our drug discovery programs. The ideal candidate will have extensive knowledge of preclinical and clinical biomarkers for Alzheimer’s, Parkinson’s or other neurodegenerative disease biology. This is a full-time, on-site position requiring physical presence in our state-of-the-art facilities to conduct hands-on research and collaborate directly with cross-functional teams.
Essential Duties/Tasks
- Lead translational biomarker efforts from target discovery through clinical development, ensuring each program has a fit-for-purpose biomarker plan that supports mechanism of action, patient selection, and pharmacodynamic readouts.
- Design and oversee biomarker assay development. Select, validate, and troubleshoot biofluid biomarker assays.
- Translate omics and pathways findings from preclinical studies into clinically actionable endpoints.
- Build quantitative PK/PD and exposure-response models linking biomarker changes to efficacy.
- Collaborate with cross-functional teams, including medicinal chemistry, pharmacology, and computational biology, to advance drug discovery projects.
- Coach scientists and research associates in assay development, study design, and data interpretation. Mentor junior scientists and provide technical guidance and leadership across the research team. Foster an inclusive, innovation-oriented culture.
- Manage external collaborations with academic institutions, CROs, and industry partners.
- Stay abreast of the latest scientific advancements and contribute to the company’s overall strategy for neurodegenerative disease research.
- Present findings and progress to senior leadership, partners, and at scientific conferences.
Preferred Education and Experience
- PhD in Neuroscience, Biology, Biochemistry, Pharmacology, or a related field with 5+ years of post-doctoral and/or industry experience.
- Deep expertise in translational biomarkers for neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, etc., with a strong track record of peer-reviewed publications.
- Hands-on experience with translational biomarkers for neurological disease.
- Proficiency with high-sensitivity biofluid platforms (Simoa, MSD, LC-MS/MS, SomaScan, O-link).
- Familiarity with spatial/transcriptomic, single-cell omics, proteomics, and metabolomics techniques.
- Experience building PK/PD and exposure-response models.
- Proven ability to lead projects and mentor scientific teams.
- Strong problem-solving and critical thinking skills, with the ability to design innovative experiments and troubleshoot complex issues.
- Excellent written and verbal communication skills, with experience presenting data to internal and external audiences.
- Experience managing collaborations with external research partners and CROs.
Preferred Skills, Qualifications, or Technical Proficiencies
- Track record interacting with FDA/EMA on biomarker qualification or companion diagnostic paths.
What We Offer
- Opportunity to work at the forefront of neuroscience and drug discovery.
- Collaborative work environment with a multidisciplinary team.
- Competitive compensation package including stock options.
- Career growth opportunities in a rapidly scaling company.
Bexorg is an equal opportunity employer. We strive to create a supportive and inclusive workplace where contributions are valued and celebrated, and our employees thrive by being themselves and are inspired to do their best work. We seek applicants of all backgrounds and identities, across race, color, ethnicity, national origin or ancestry, citizenship, religion, sex, sexual orientation, gender identity or expression, veteran status, marital status, pregnancy or parental status, or disability. Applicants will not be discriminated against based on these or other protected categories or social identities. Bexorg will also consider for employment qualified applicants with criminal histories in a manner consistent with applicable federal, state and local law.
Please be advised that Bexorg operates a Biosafety Level 2 (BSL-2) laboratory. All laboratory personnel must adhere to strict safety protocols involving the handling, storage, and disposal of potentially hazardous biological agents. Regular participation in safety training and compliance with institutional safety policies are mandatory to ensure a safe work environment and to mitigate risks.