Histotechnologist
About Nudge
At Nudge, our mission is to develop the best technology for interfacing with the brain to improve people's lives. We're starting with an approach that we believe can help the most people the fastest, and also allow us to learn as much about the brain as possible: developing a non-invasive, ultrasound-based device that can stimulate and image the brain at high resolution and depth. This is a vertically integrated effort building cutting-edge hardware, software, and research capabilities to create products that can benefit millions — and eventually billions — of people.
To succeed, we need to assemble world-class teams across everything we do. We hire people who are exceptional at their craft, believe hard things are worth doing, and execute relentlessly — people who expect the highest levels of both rigor and integrity from each other.
About the role
We’re looking for a Histotechnologist to own and execute histology workflows at Nudge, focused primarily on mouse and rat brain tissue. You’ll be responsible for building the full histology pipeline: perfusion, prosection, embedding, sectioning, staining, and imaging — across both traditional and cutting-edge techniques, to understand the mechanisms of ultrasonic neuromodulation.
As a Histotechnologist at Nudge, you will:
Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome
Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms
Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole-brain and thick-section imaging
Prepare cleared tissue for light sheet fluorescence microscopy and volumetric 3D imaging
Operate and maintain automated sectioning and tissue processing systems
Prepare and process samples for spatial omics platforms, including multiplexed protein imaging and spatial transcriptomics, with both RNA- and protein-based tagging approaches
Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality
Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions
About you
3+ years of hands-on experience in histotechnology, with significant time spent processing rodent brain tissue
Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry
Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)
Familiarity with automated staining and sectioning platforms
HT(ASCP) certification or equivalent training; Bachelor’s degree in biology, neuroscience, or a related field preferred
High integrity and strong professional judgment