Expert Statistician | AAVantgarde Bio
GT was founded in 2019 by a former Apple, Nest, and Google executive. GT’s mission is to connect the world’s best talent with product careers offered by high-growth companies in the UK, USA, Canada, Germany, and the Netherlands.
On behalf of AAVantgarde Bio, GT is looking for an Principal Statistician, interested in healthtech and ophthalmology domains.
About the Client & the Project
AAVantgarde Bio is an international clinical-stage biotechnology company developing next-generation gene therapies for inherited retinal diseases. The company has created two proprietary technologies that enable the delivery of large genes into human cells, overcoming one of the major limitations of traditional gene therapy approaches. These platforms are already being validated in clinical trials, with the potential to expand into multiple disease areas beyond ophthalmology. Headquartered in Milan, AAVantgarde operates with a growing international team and a strong focus on translating advanced science into real patient impact. The company was founded by Professor Alberto Auricchio, a globally recognised pioneer in gene therapy.
Founded: 2021
Series B startup
About the Role
The Principal Statistician will provide senior-level statistical expertise to support AAVantgarde Bio’s clinical development programs. This role combines hands-on statistical programming, advanced methodological expertise, and independent scientific judgement, working closely with cross-functional teams across Clinical, Medical, Regulatory, Data Management, and Biometrics.
A strong focus will be placed on ophthalmology clinical trials and endpoints, ensuring analyses are scientifically rigorous, clinically interpretable, and aligned with regulatory expectations.
Position Goals:
Provide strategic and hands-on statistical leadership across clinical development programs
Design, analyse, and interpret clinical trial data to support high-quality scientific and business decisions
Ensure statistical deliverables are accurate, inspection-ready, and aligned with regulatory standards
Act as a trusted statistical thought partner across the organisation
Responsibilities:
Provide senior statistical expertise for the design, analysis, and interpretation of clinical trials across clinical development programs
Define statistical strategies including estimands, sample size, interim analyses, and analytical approaches
Perform hands-on statistical programming and review of analysis datasets, tables, figures, and listings
Apply advanced statistical methodologies and ensure alignment with regulatory expectations
Support the definition, analysis, and interpretation of ophthalmology-specific clinical endpoints
Ensure high-quality, accurate, and inspection-ready statistical deliverables
Collaborate closely with Clinical, Medical, Regulatory, Data Management, and Biometrics teams
Contribute to statistical sections of protocols, SAPs, clinical study reports, and regulatory documents
Act as a statistical thought partner, clearly communicating results and implications to non-statistical stakeholders
Requirements:
Senior-level expertise in clinical trial statistics within biotech or pharmaceutical environments
Strong hands-on statistical programming experience
Deep understanding of advanced statistical methodologies
Experience supporting regulatory submissions and inspection-ready deliverables (FDA / EMA)
Ability to work independently in a fast-paced, evolving organisation
Nice-to-have
Prior experience in ophthalmology or rare diseases
Experience with external or historical control data
Exposure to Bayesian or simulation-based methods
Soft Skills
High attention to detail and scientific integrity
Clear communication of complex statistical concepts to non-statistical audiences
Proactive, collaborative, and intellectually curious mindset
Ability to manage changing priorities and tight timelines
Interview Steps
GT interview with Recruiter
Client interview
Final interview
We go beyond usual perks… By working with us, you will get:
Health insurance.
Psychotherapy coverage.
Sport coverage.
Learning budget.
18 business days of paid vacation days per year
Paid sick leaves.
All public holidays are paid days off.
GT working model:
You will work directly with a client through our Extended Team model. We try to do things differently and put our efforts into integrating you as deeply as possible into the client’s team. You work with the same tools and technologies as they do and are managed directly by the client without any intermediary in between. We help you build relationships and create an environment where you genuinely feel like a member of the client’s team. We also encourage trips to a client and join teambuilding and after-work activities. Our Extended Team model is focused on long-term projects that last over several years.